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瘤通过循环的癌细胞自我播种.
Mi-Young Kim1, Thordur Oskarsson, Swarnali Acharyya
1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Cell
|January 13, 2010
概括
癌细胞可以回到原来的瘤,这一过程被称为瘤自我播种. 这种侵略性的循环瘤细胞 (CTC) 行为加速了癌症的生长,并可能解释手术后局部复发.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 转移研究 转移研究
背景情况:
- 转移通常被视为癌细胞从原发性瘤向遥远部位的单向扩散.
- 传播后循环瘤细胞 (CTC) 的命运和行为尚未完全理解.
研究的目的:
- 研究循环瘤细胞 (CTC) 殖民其原始瘤的潜力.
- 在临床前癌症模型中确定这种"瘤自我播种"过程的机制和后果.
主要方法:
- 使用了乳腺癌,结肠癌和黑色素瘤的小鼠模型.
- 分析了特定细胞因子 (IL-6,IL-8),酶 (MMP1/collagenase-1) 和细胞骨成分 (fascin-1) 在CTC透中的作用.
- 研究了自我播种对瘤生长,血管生成和树皮细胞招募的影响,检查了诸如CXCL1.1这样的因素.
主要成果:
- 证明积极的CTC,包括转移到骨,肺或大脑的转移性热带细胞,可以殖民其主要瘤 (瘤自我播种).
- 确定IL-6和IL-8是CTC的关键吸引剂,MMP1/collagenase-1和fascin-1是入乳腺瘤的媒介.
- 表明自我播种加速瘤生长,血管新生和 stromal 招募,部分通过CXCL1.
结论:
- 循环瘤细胞 (CTC) 可以殖民其原始瘤,挑战单向转移模型.
- 瘤的自我播种,由积极的CTC和特定的分子因素介导,可以增强瘤的进展.
- 这个过程可以阐明瘤特征,预后和看似完全切除后局部复发之间的联系.
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