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Updated: May 6, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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通过将全与ATP结合部位抑制剂结合起来,准Bcr-Abl

Jianming Zhang1, Francisco J Adrián, Wolfgang Jahnke

  • 1Dana-Farber Cancer Institute, Harvard Medical School, Department of Cancer Biology, Seeley G. Mudd Building 628, Boston, Massachusetts 02115, USA.

Nature
|January 15, 2010
PubMed
概括

研究人员开发了GNF-5,一种性抑制剂,向Bcr-Abl myristate结合部位. 将GNF-5与ATP竞争性药物的结合克服了耐药性,显示了治疗Bcr-Abl驱动癌症的前景.

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