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黑猩猩和人类的Y染色体在结构和基因含量方面有显著差异
Jennifer F Hughes1, Helen Skaletsky, Tatyana Pyntikova
1Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
Nature
|January 15, 2010
概括
在过去的600万年里,人类和黑猩猩的Y染色体迅速进化,在基因含量和结构上显示出显著的差异. 这种由精子生产和交配行为等因素驱动的快速进化表明,在较旧的Y染色体中,主要的改造而不是简单的基因损失.
科学领域:
- 遗传学 是一个遗传学.
- 进化生物学 进化生物学
- 进行比较基因组学.
背景情况:
- 由于数量有限的测序数据,Y染色体的近期演变不太清楚.
- 主流理论表明,Y染色体主要通过基因丢失进化,导致静止.
研究的目的:
- 测序黑猩猩Y染色体的雄性特异区域 (MSY) 以与人类MSY进行比较.
- 为了研究较老,高度进化的Y染色体的进化动态.
主要方法:
- 完成了黑猩猩MSY的测序.
- 人类和黑猩猩MSY序列的比较分析.
主要成果:
- 人类和黑猩猩的MSY在序列结构和基因含量方面表现出极大的差异.
- 黑猩猩MSY有更多的平行体,但与最后一个共同祖先相比,它失去了重要的基因家族.
- 在过去的600万年里,发生了快速的进化.
结论:
- Y染色体的进化不仅仅是基因丢失;较旧的Y染色体经历了显著的更新.
- 驱动分歧的因素包括精子生产,遗传车,重组和交配行为.
相关概念视频
The Y Chromosome Determines Maleness
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Synteny and Evolution
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral chromosome underwent...
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral chromosome underwent...
X and Y Chromosomes
Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
Chromosome Structure
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
Chromosome Structure
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
Pedigree Analysis
Overview

