患有先天性异常的儿童的20年生存率:基于人口的研究
Peter W G Tennant1, Mark S Pearce, Mary Bythell
1Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Lancet (London, England)
|January 23, 2010
概括
先天性异常影响生存,受影响个体的20年生存率为85.5%. 根据异常类型的生存率有很大差异,这凸显了对量身定制的护理策略的需求.
科学领域:
- 医学研究 医学研究
- 儿科卫生健康 儿科卫生健康
- 公共卫生 公共卫生
背景情况:
- 先天性异常是婴儿死亡的主要原因.
- 对于许多异常类型,对第一年以后的长期存活的知识是有限的.
- 这项研究通过估计高达20岁的生存率来解决知识差距.
研究的目的:
- 估计各种先天性异常组和亚型的长期存活率.
- 确定影响先天性异常个体生存的因素.
- 为家庭和医疗保健专业人员提供数据,用于未来的护理规划.
主要方法:
- 利用了1985-2003年英国北部先天性异常调查 (NorCAS) 的数据.
- 通过使用欧洲先天性异常监测 (EUROCAT) 的指导方针,按组,亚型和综合征分类异常.
- 采用卡普兰-梅尔方法来估计生存率和考克斯比例危险回归来进行因子分析.
主要成果:
- 在患有先天性异常的个体中,整体20年生存率为85.5%.
- 根据异常类型的生存率有很大差异,从66.2% (神经系统) 到97.6% (面部裂) 之间.
- 在研究期间,胎儿异常终止的比例增加了,出生年份是生存的重要预测因素.
结论:
- 对于先天性异常组和亚型的生存估计对于明智的决策至关重要.
- 这些数据将有助于家庭和医疗保健专业人员了解预后和计划护理.
- 这些发现强调了对先天性异常结果的持续研究的重要性.
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