瓣膜性主动脉瓣狭窄的进展:一项长期回顾性研究

S W Davies1, A H Gershlick, R Balcon

  • 1Cardiac Department, London Chest Hospital, U.K.

European heart journal
|January 1, 1991
PubMed

主动脉瓣狭窄是一种潜在的严重疾病。尽管从轻度发展为重度主动脉瓣狭窄的进程已被广泛认知,但关于其进展速度的具体数据仍较为有限。本研究回顾性分析了65例主动脉瓣狭窄患者的临床结局和心导管检查资料。所有患者均接受过至少两次心导管检查,两次检查之间的间隔时间为1至17年(平均7年)。在60例患者中,主动脉瓣跨瓣压差升高,中位值从10 mmHg(范围0–60 mmHg)上升至52 mmHg(范围15–120 mmHg)。压差的平均增长速率为每年6.5 mmHg,在首次心导管检查时伴有主动脉瓣钙化或主动脉瓣反流的患者中,压差增长速度显著更快(P < 0.02)。本研究表明,主动脉瓣狭窄的进展可能非常迅速,且与瓣膜钙化和反流相关。对于存在轻度或中度主动脉瓣压差但因合并冠状动脉疾病或二尖瓣疾病而拟行心脏外科手术的患者,应考虑同期行主动脉瓣置换术。

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