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Updated: Jun 16, 2026

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
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Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

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设计的半合成蛋白抑制剂Ub/Ubl E1激活酶的设计半合成蛋白抑制剂

Xuequan Lu1, Shaun K Olsen, Allan D Capili

  • 1Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 422, New York, New York 10065, USA.

Journal of the American Chemical Society
|January 27, 2010
PubMed
概括

开发了新的蛋白质抑制剂,向全方位素 (Ub) 和全方位素类修饰剂 (Ubl) 激活酶 (E1s). 这些半合成工具可以选择性地抑制E1酶,为无处不在和SUMOylation通路提供了强大的洞察力.

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