功能和白蛋白尿与艾滋病毒感染者的心血管事件之间的关联
Andy I Choi1, Yongmei Li, Steven G Deeks
1Department of Medicine, San Francisco Veterans Affairs Medical Center, and University of California, San Francisco, USA. andy.choi@ucsf.edu
Circulation
|January 27, 2010
概括
功能和白蛋白尿是艾滋病毒感染者心血管疾病 (CVD) 和心力衰竭风险的关键指标. 监测这些标志物有助于更好地对这一群体进行心血管疾病风险分层.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 传染病 (艾滋病毒/艾滋病)
背景情况:
- 心血管疾病 (CVD) 是艾滋病毒感染者死亡的主要原因.
- 艾滋病毒感染人口中心血管疾病的风险标志物尚未确定.
- 这项研究研究功能和白尿作为艾滋病毒中潜在的心血管疾病风险标志物.
研究的目的:
- 检查功能和专尿与动脉样硬化心血管疾病风险的纵向测量之间的关联.
- 评估功能和白蛋白尿与艾滋病毒感染个体心力衰竭风险之间的关联.
主要方法:
- 追踪了一项全国性样本,包括17264名在退伍军人卫生管理局接受护理的艾滋病毒感染者.
- 记录了发生的心血管疾病 (冠状动脉,脑血管,外周动脉疾病) 和心力衰竭.
- 使用多变量回归分析来调整潜在的混因素.
主要成果:
- 提升的白膜尿和降低估计的淋巴膜过率 (eGFR) 与心血管疾病和心力衰竭的风险增加显著相关.
- 具有最低EGFR (<30毫升/分钟/1.73米2) 和最高白蛋白尿 (≥300毫克/分升) 的个体患心血管疾病和心力衰竭的风险增加了6倍.
- 特定的eGFR下降和白蛋白尿的增加显示了对心血管疾病和心力衰竭风险的剂量依赖性增加.
结论:
- 降低功能 (eGFR) 和白蛋白尿的存在是艾滋病毒感染个体中心血管疾病和心力衰竭的强有力的预测因素.
- 这些标志物为心血管疾病风险分层提供了补充的预后信息.
- 综合功能和白尿评估可以改善艾滋病毒患者心血管风险管理.
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