1996年至2003年在德克萨斯州出生的具有功能单心室的婴儿在前5年的死亡率
David E Fixler1, Wendy N Nembhard, Jason L Salemi
1Department of Pediatrics, University of Texas Health Science Center, Dallas, USA. david.fixler@childrens.com
Circulation
|January 27, 2010
概括
1996-2003年间,功能单心室的婴儿的五年生存率显著改善. 影响生存的关键因素包括缺陷类型,心脏外异常和种族/种族.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 遗传性心脏病研究 遗传性心脏病研究
- 公共卫生监督 公共卫生监督
背景情况:
- 功能单心室的婴儿面临着高的早期死亡风险.
- 现有的生存数据往往排除了手术前或转移前的死亡.
- 基于人群的研究对于全面的结果评估至关重要.
研究的目的:
- 估计功能单心室的婴儿的5年生存率.
- 为了确定影响这一群体生存的因素.
- 评估随着时间的推移对结果的改进.
主要方法:
- 利用了德克萨斯州出生缺陷登记处1996-2003年的数据.
- 链接注册表数据与州和国家重要记录以进行生存分析.
- 检查了缺陷类型,出生特征和人口统计学对生存的影响.
主要成果:
- 五年存活率因缺陷而异:低质左心综合征 (HLHS) 38.0%,单心室 (SV) 56.1%,肺动脉动完整的心室 (PAIVS) 55.7%,三动脉动 (TA) 74.6%.
- 心脏外异常增加了84%的死亡风险.
- 种族/种族差异指出:非西班牙裔黑人 (41%更高的风险),西班牙裔 (26%更高的风险) 与非西班牙裔白人. 与1996-2000年相比,2001-2003年生存率有所改善 (47%的风险降低).
结论:
- 观察到5年生存率的显著改善,特别是在HLHS和SV.
- 需要进一步的研究,以了解种族/民族和区域的结果差异.
- 基于人口的数据为先天性心脏缺陷生存趋势提供了关键的见解.
更多相关视频
相关概念视频
02:57Meiosis vs. Mitosis
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...