结合聚与序列设计的:合成和组装聚----酸) -b-卷-卷的共聚合物
Hana Robson Marsden1, Jan-Willem Handgraaf, Fabio Nudelman
1Department of Soft Matter Chemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
Journal of the American Chemical Society
|January 30, 2010
概括
研究人员开发了新的多块设计的仿真体. 这些自组装可以创建可调节的纳米结构,用于潜在的向药物递送应用.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 基于的材料为先进的应用提供了独特的特性.
- 设计合体可以将不同的功能结合起来.
- 现有的方法往往难以将大型聚类块纳入自组装系统.
研究的目的:
- 为了合成和表征一种新的类型的多块设计的.
- 探索这些合体的自我组装能力,使它们成为纳米结构.
- 展示一种模块化方法,用于创建功能性基纳米材料.
主要方法:
- 一个卷轴-卷轴形成的固体相合成 (E).
- 从E开始的-基-基-l-氨酸N-碳素化的环开聚合.
- 使用互补 (E和K) 之间的卷轴-卷轴相互作用的非共价组合.
- 使用动态光散射,显微镜 (SEM,冷-TEM) 和光谱 (CD,光) 的表征.
主要成果:
- 成功合成了多块设计的,具有不同的聚----氨酸 (PBLG) 块长度 (36-250残留物).
- 在中性pH的水溶液中证明了自我组装成纳米结构 (聚合物,双细胞).
- 通过模块化块组合对纳米结构大小,形态和表面功能进行调节控制.
- 卷轴-卷轴相互作用使PBLG块与水友性块的非共价连接成为可能.
结论:
- 一个新型的聚块设计的新型类型已经成功创建.
- 这些嵌合体为构建基于的纳米结构提供了一个多功能平台.
- 模块化系统允许精确控制纳米结构的特性.
- 潜在的应用包括由于封装和功能化能力的目标药物输送车辆.
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