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相关概念视频

Golgi Matrix Proteins01:12

Golgi Matrix Proteins

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Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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The Extracellular Matrix01:29

The Extracellular Matrix

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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
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The Extracellular Matrix01:42

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Cell-matrix's Response to Mechanical Forces01:13

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Extracellular Matrix01:26

Extracellular Matrix

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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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The Microscopy-Based Assay to Study and Analyze the Recycling Endosomes using SNARE Trafficking
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细胞内膜矩阵 细胞内膜矩阵

Giorgio Scita1, Pier Paolo Di Fiore

  • 1IFOM, the FIRC Institute for Molecular Oncology Foundation, at the IFOM-IEO Campus, Via Adamello 16, 20139, Milan, Italy. giorgio.scita@ifom-ieo-campus.it

Nature
|January 30, 2010
PubMed
概括
此摘要是机器生成的。

细胞内细胞分裂,一个细胞过程,不仅仅是营养的吸收;它巧妙地组织细胞信号网络. 最近的发现揭示了它更深入地融入了细胞组织,被称为细胞组织.

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科学领域:

  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • 传统上,内细胞分裂被视为营养物质和膜分子内部化的机制.
  • 新兴的研究表明,内细胞体在细胞组织和信号传递中起着更复杂的作用.

研究的目的:

  • 为了探索除了营养摄取之外的内细胞分裂的扩大作用.
  • 研究内细胞酶作为细胞信号回路的关键组织者.
  • 了解细胞内的整合到更深层的细胞"总体计划".

主要方法:

  • 综述最近关于内细胞分裂的研究结果.
  • 分析了内细胞转移和信号分辨率中的内细胞化作用.
  • 概念化"内细胞矩阵"作为理解细胞组织的框架.

主要成果:

  • 细胞内核作为信号电路的主组织者,在空间和时间中解决信号.
  • 许多新发现的内细胞功能挑战了关于细胞内贩运的正规观点.
  • 内细胞分裂似乎深深地融入了细胞的基本信号网络.

结论:

  • 内细胞形成在组织细胞信号传递中起着至关重要的作用,超越了简单的内化.
  • "内细胞矩阵"的概念为细胞组织提供了新的视角.
  • "内细胞基质"的进一步解可能会揭示细胞结构的基本方面.