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Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models
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Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models

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Hsp70稳定了溶酶体,并逆转了与尼曼-皮克病相关的溶酶体病理

Thomas Kirkegaard1, Anke G Roth, Nikolaj H T Petersen

  • 1Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark.

Nature
|January 30, 2010
PubMed
概括

热冲击蛋白70 (Hsp70) 通过与双单糖酸 (BMP) 结合来稳定溶解体,从而增强酸胺基酶 (ASM) 的活性. 这一发现为溶酶体储存障碍和癌症提供了潜在的新疗法.

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