在低密度脂蛋白受体缺乏的小鼠中,定期运动训练可以预防大动脉膜疾病
Yasuharu Matsumoto1, Volker Adams, Saskia Jacob
1Department of Cardiology, Heart Center Leipzig, University of Leipzig, Strümpellstrasse 39, D-04289 Leipzig, Germany. yasuharu@muj.biglobe.ne.jp
Circulation
|February 4, 2010
概括
通过保持内皮质完整性和减少炎症,定期运动训练可以预防小鼠的大动脉硬化. 这项研究表明,持续炼是心血管健康的关键.
科学领域:
- 心血管研究研究心血管研究
- 运动生理学 运动生理学
- 动脉样硬化研究 研究动脉样硬化
背景情况:
- 退行性大动脉膜疾病是一个越来越令人担忧的问题.
- 众所周知,运动训练 (ET) 对心血管健康有益.
- ET可以通过减少氧化应激和提高氧化的生物可用性来改善大动脉膜疾病.
研究的目的:
- 研究定期运动训练对预防大动脉硬化症的影响.
- 探索运动对大动脉的保护作用的潜在机制.
主要方法:
- 缺乏低密度脂蛋白受体的小鼠被食一种富含胆固醇的饮食.
- 在16周的时间里,小鼠被分为静止,常规ET和偶尔ET组.
- 进行了组织学分析,免疫组织化学和基因表达分析.
主要成果:
- 与静止控制组相比,定期ET显著降低了大动脉门厚度.
- 运动保护了内皮完整性,并减少了炎症和氧化应激的标志物.
- ET抑制了关键的骨质生成途径,并增加了循环中的fetuin-A水平.
结论:
- 在小鼠模型中,定期的运动训练在预防大动脉硬化方面是有效的.
- 机制包括维护内皮完整性,减少炎症和氧化应激,并抑制骨质生路径.
- 持续的运动显示出对大动脉膜健康的显著益处.
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