Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same author

Temporal Trends in the Complexity of Nephrology Inpatients: A Population-Based Cohort Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

Identification of Maintenance Dialysis Recipients From an Electronic Clinical Information System and Effects on Estimates of Incidence and Prevalence.

Kidney medicine·2026
Same author

Reply to Odo-Interpreting Trends in Cardiac Imaging Use Across Alberta.

The Canadian journal of cardiology·2026
Same author

A parallel private-pay system will worsen access to publicly funded surgery.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same author

Ten-Year Anniversary of the Advisory Panel on Healthcare Innovation Report: Assessing Progress and What Is Left to Do.

HealthcarePapers·2026
Same journal

Alcohol-Related Liver Disease: A Review.

JAMA·2026
Same journal

Online Prescribing of GLP-1 Receptor Agonists.

JAMA·2026
Same journal

Using AI Disagreement to Expose Gaps in Coverage Rules.

JAMA·2026
Same journal

Randomized Trials in Pregnancy.

JAMA·2026
Same journal

Randomized Trials in Pregnancy-Reply.

JAMA·2026
Same journal

WHO Issues Guidelines for Treating Ebola and Marburg Viruses.

JAMA·2026
查看所有相关文章

相关实验视频

Updated: Jun 16, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

功能,蛋白尿和不良结果之间的关系.

Brenda R Hemmelgarn1, Braden J Manns, Anita Lloyd

  • 1Department of Medicine, University of Calgary, Calgary, Alberta, Canada. brenda.hemmelgarn@albertahealthservices.ca

JAMA
|February 4, 2010
PubMed
概括
此摘要是机器生成的。

蛋白尿症显著增加了死亡和功能衰竭等不良结果的风险,即使功能正常 (eGFR). 这凸显了需要将蛋白尿纳入慢性病风险评估,以更好地管理患者的必要性.

相关实验视频

Last Updated: Jun 16, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

科学领域:

  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 心脏病学 心脏病学
  • 公共卫生 公共卫生

背景情况:

  • 目前慢性病 (CKD) 的分期依赖于估计的淋巴细胞过率 (eGFR),但不包括蛋白尿风险分层.
  • 蛋白尿是独立与慢性病患者的不良临床结果相关的.

研究的目的:

  • 调查降低GFR和蛋白尿与不良临床结果的联合关联.
  • 为了确定蛋白尿是否会改变一般成年人群中与EGFR水平相关的风险.

主要方法:

  • 一项针对加拿大阿尔伯塔省920985名成年人的社区队列研究 (2002-2007).
  • 使用实验室注册数据来测量eGFR和蛋白尿 (尿液测量棒或白蛋白-肌素比率 (ACR)).
  • 评估结果包括全因死亡率,心肌梗塞和功能衰竭的进展.

主要成果:

  • 较高的蛋白尿水平与所有原因死亡率,心肌梗塞和功能衰竭的增加有关,独立于eGFR.
  • 严重蛋白尿和eGFR≥60mL/min/1.73m2的个体与中度eGFR和无蛋白尿的人相比,死亡风险增加了一倍以上.
  • 对于ACR和其他不良结果 (如末期脏病) 也观察到类似的关联.

结论:

  • 蛋白尿是CKD中不良结果的独立预测因素.
  • 死亡,心肌梗塞和功能衰竭的风险在任何给定的eGFR中被更高的蛋白尿水平放大.
  • 临床指南应考虑将蛋白尿评估纳入综合性CKD风险分层.