在慢性髓性白血病中,TGF-β-FOXO信号维持白血病发起细胞

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Updated: Jun 16, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Kazuhito Naka1, Takayuki Hoshii, Teruyuki Muraguchi

  • 1Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-0934, Japan. kazunaka@kenroku.kanazawa-u.ac.jp

Nature
|February 5, 2010
PubMed
概括

缺乏Foxo3a显著降低慢性髓性白血病 (CML) 的干细胞活性. 针对TGF-β-FOXO通路与伊马替尼一起,为CML根除提供了一个新的策略.

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