在一个人群中,血压与血清脂质之间的关联. 特罗姆索研究的研究
1Institute of Community Medicine, University of Tromsø, Norway.
Circulation
|April 1, 1991
概括
高血压与不健康的血脂特征有关,特别是总和非HDL胆固醇. 这些关联因年龄和性别而异,表明影响心脏病风险的生物学相互关系.
科学领域:
- 心血管流行病学心血管流行病学
- 代谢综合征研究研究
背景情况:
- 高血压与动脉动脉血脂有关,但研究结果在不同人群中存在差异.
- 了解血压和脂质关系可能会澄清高血压在冠心病 (CHD) 风险中的作用.
研究的目的:
- 检查血压和血清脂质水平 (总胆固醇,高密度胆固醇,非高密度胆固醇,甘油三) 之间的横截面关联.
- 调查这些关系如何根据性别和年龄组不同.
主要方法:
- 对8,081名男性 (20-54岁) 和7,663名女性 (20-49岁) 的截面分析.
- 分层分析和多变量方法对人体测量和生活方式因素进行了控制.
- 评估血清总胆固醇,高密度胆固醇,非高密度胆固醇和甘油三与静缩和静缩血压的关系.
主要成果:
- 总胆固醇和非高密度胆固醇在两性中随着血压升高而显著增加.
- 年龄和性别改变了胆固醇与血压的关联;体重指数是一个显著的调节者.
- 甘油三水平随着血压的上升而上升,特别是在非瘦身的个体中;高脂胆固醇在高酒精消费者中显示出正相关性.
结论:
- 血压和血脂之间存在生物学相互关系.
- 这些相互关系可能有助于将高血压与冠状动脉疾病风险增加联系起来的机制.
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