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A Mass Spectrometry-Based Proteomics Approach for Global and High-Confidence Protein R-Methylation Analysis
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在大型蛋白质中的甲基组的全面和经济有效的NMR光谱学

Renee Otten1, Byron Chu, Karla D Krewulak

  • 1Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Journal of the American Chemical Society
|February 13, 2010
PubMed
概括

这项研究引入了一种具有成本效益的NMR方法,用于在蛋白质中分配甲基,增强结构和动态研究. 该技术使用同位素标记来实现高灵敏度和分辨率,从而能够对更大的蛋白质系统进行详细分析.

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