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桥接的p53-hDM2复合的β(3) - 抑制剂:亲和力和细胞透性之间的相关性

Arjel D Bautista1, Jacob S Appelbaum, Cody J Craig

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.

Journal of the American Chemical Society
|February 18, 2010
PubMed
概括

研究人员使用疏水桥改善了贝塔的细胞透性,贝塔是模仿蛋白质的分子. 这增强了它们作为治疗剂和研究工具的潜力,通过增加细胞吸收而不会增加显著的质量.

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...