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相关概念视频

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism

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相关实验视频

Updated: Jun 16, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

在一个多位置基因网络中显著地古老的平衡多态.

Chris Todd Hittinger1, Paula Gonçalves, José Paulo Sampaio

  • 1Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

Nature
|February 19, 2010
PubMed
概括
此摘要是机器生成的。

这项研究揭示了酵母中一种新型的遗传变异,整个基因网络在数百万年内保持在不同的状态. 这种复杂的多态性,涉及银河糖 (GAL) 基因网络,挑战了简单的进化模型.

更多相关视频

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

相关实验视频

Last Updated: Jun 16, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

科学领域:

  • 进化遗传学的进化遗传学
  • 人口遗传学 人口遗传学
  • 分子进化的分子进化.

背景情况:

  • 局部适应通常是由多个相互作用的基因驱动的,由于重组,这给进化模型带来了挑战.
  • 单位模式无法解释物种内部复杂的遗传变异的维持.

研究的目的:

  • 识别和表征新型的物种内基因变异的新形式.
  • 研究一个物种内的复杂基因网络的进化历史和维护机制.

主要方法:

  • 在Saccharomyces kudriavzevii菌株的基因组测序.
  • 比较基因组学分析基因网络状态.
  • 对基因功能和调控作用的实验验证.

主要成果:

  • 在Saccharomyces kudriavzevii中发现了银河糖 (GAL) 利用基因网络的两个不同的状态:功能性 (葡萄牙菌株) 和非功能性伪基因 (日本菌株).
  • 证明这些多态性一直保持在物种的进化历史上,早于最近的基因流动.
  • 确定了GAL3和GAL80调节基因的失活是这些独特网络状态的起源和持久性的关键因素.

结论:

  • 引入了一种新型的平衡,无关联的基因网络多态性模型,作为种内变异的重要因素.
  • 表明这种复杂的遗传变异,在长期的进化时间范围内保持,可能比以前认为的更常见.