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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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针对蛋白质工程的特定序列的Ni (II) 依赖性键水解. 组合图书馆确定最佳序列的最佳序列

Artur Krezel1, Edyta Kopera, Anna Maria Protas

  • 1Laboratory of Protein Engineering, Faculty of Biotechnology, University of Wrocław, Tamka 2, 50-137 Wrocław, Poland.

Journal of the American Chemical Society
|February 20, 2010
PubMed
概括

离子 (Ni(II)) 在含有Ala-Ser/Thr序列的中催化特定键的水解. 在Xaa和Zaa位置的大型,疏水性氨基酸提高了水解速率,有助于解释机制和生物技术应用.

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...