结合的 (Z) -enynes的选择性乳化
Wei Zhang1, Suqing Zheng, Na Liu
1School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, USA.
Journal of the American Chemical Society
|March 3, 2010
概括
这项研究引入了一种新的催化方法,用于酶的选择性乳化. 这一过程有效地产生具有高立体选择性的奇拉和乳.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 合成方法论 合成方法论
背景情况:
- 对药品而言,酶选择性合成至关重要.
- 目前正在开发用于复杂分子合成的新型催化方法.
- 乳化提供了一条通往功能化的异环环的途径.
研究的目的:
- 开发一种催化式的enantioselective syn-1,4-bromolactonization 的结合 (Z) -enynes. 一个催化式的 enantioselective 的 syn-1,4-bromolactonization 的结合 (Z) -enynes. 一个催化式的 enantioselective 的 syn-1,4-bromolactonization 的结合 (Z) -enynes.
- 为了高效地合成二,三,四替代烯和乳异环.
- 为了研究性催化剂的机制.
主要方法:
- 催化酶选择性合成-1,4-乳化反应.
- 结合 (Z) - 酶因作为基质的使用.
- 使用一种性催化剂和N-糖胺 (N-bromosuccinimide,NBS).
主要成果:
- 实现了高的二聚体比率 (>20:1).
- 获得高达99%的反体过剩.
- 替代和乳的高效和立体选择性合成.
结论:
- 已经确立了 (Z) -enynes的新型催化酶选择性乳化.
- 该方法提供了获取有价值的性醇和乳的途径.
- 性催化剂可能充当双功能试剂.
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