Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chain Reactions01:29

Chain Reactions

Chain reactions involve highly reactive transient species, such as atoms or free radicals, as intermediates. These intermediates facilitate rapid reactions over an extended period. The process includes a series of steps: a reactive intermediate is consumed, reactants are converted to products, and the intermediate is regenerated. This cycle enables continuous repetition, amplifying the production of products with a small amount of intermediate. Chain reactions often utilize free radicals as...
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the generated carbocation,...
Anionic Chain-Growth Polymerization: Mechanism01:04

Anionic Chain-Growth Polymerization: Mechanism

The mechanism for anionic chain-growth polymerization involves initiation, propagation, and termination steps. In the initiation step, a nucleophilic anion, such as butyl lithium, initiates the polymerization process by attacking the π bond of the vinylic monomer. As a result, a carbanion, stabilized by the electron‐withdrawing group, is generated. The resulting carbanion acts as a Michael donor in the propagation step and attacks the second vinylic monomer, which acts as a Michael acceptor.
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Electronegatively substituted adamantyl units accelerate chemiexcitation of 1,2-dioxetane luminophores while preserving chemical stability.

Chemical science·2026
Same author

Chemiluminescent Probes Allow for the Rapid Identification of Colibactin-Producing Bacteria.

JACS Au·2026
Same author

Sunlight-powered photodynamic therapy for painless diabetic wound care.

National science review·2026
Same author

A chemiluminescence assay targeting granzyme A activity for monitoring inflammatory bowel disease.

Nature biomedical engineering·2026
Same author

Chemiluminescent probes allow for the rapid identification of colibactin-producing bacteria.

bioRxiv : the preprint server for biology·2026
Same author

Chemiluminescent probes for imaging cysteine cathepsin activity.

Bioorganic & medicinal chemistry letters·2025

相关实验视频

Updated: Jun 15, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

两组分树突连锁反应:实验和理论.

Eran Sella1, Ariel Lubelski, Joseph Klafter

  • 1Department of Organic Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.

Journal of the American Chemical Society
|March 3, 2010
PubMed
概括

一种新的双组分树突连锁反应提供了指数级信号放大,以提高诊断灵敏度. 这种新方法显著改善了对过氧化等分析物的检测.

科学领域:

  • 分析化学 分析化学
  • 生物化学 生物化学
  • 纳米技术纳米技术

背景情况:

  • 提高诊断技术的灵敏度对于早期疾病检测和监测至关重要.
  • 信号放大机制提供了一个有前途的途径,以提高各种分析物的检测极限.

研究的目的:

  • 开发一种新的双组分树突链反应,用于指数级信号放大.
  • 为了证明该系统在检测过氧化的有效性,提高了灵敏度.
  • 创建一个数学模型来模拟反应动力学.

主要方法:

  • 开发一个由两部分组成的树突连锁反应系统.
  • 利用连锁反应产生感兴趣的分析物,启动进一步的诊断周期.
  • 实验验证和与经典探测方法的比较.
  • 一组件和两组件反应拆卸动力学的数学建模.

主要成果:

  • 实现了诊断信号的指数级放大.
  • 与经典探测器相比,对过氧化检测的信号强度明显更高.
  • 开发了一种与反应动力学实验数据准确相关的数学模型.

结论:

更多相关视频

Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points
09:30

Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points

Published on: March 2, 2011

A Computer-assisted Multi-electrode Patch-clamp System
11:01

A Computer-assisted Multi-electrode Patch-clamp System

Published on: October 18, 2013

相关实验视频

Last Updated: Jun 15, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points
09:30

Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points

Published on: March 2, 2011

A Computer-assisted Multi-electrode Patch-clamp System
11:01

A Computer-assisted Multi-electrode Patch-clamp System

Published on: October 18, 2013

  • 开发的双组分树突连锁反应系统为高度敏感的分析物检测提供了强大的工具.
  • 该系统的模块化和灵活性允许调整以检测更广泛的分析物.
  • 数学建模有助于理解和优化反应动态.