蛋白质聚合物和新型普雷西林基因变异在异常扩张心肌病的异常扩张心肌病

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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Davide Gianni1, Airong Li, Giuseppina Tesco

  • 1Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA 02125, USA.

Circulation
|March 3, 2010
PubMed
概括

异常扩张性心肌病 (iDCM) 可能源于心脏细胞中异常的蛋白质聚合,类似于痴呆症. 这种聚合会影响的处理和 presenilin-1 (PSEN1) 基因表达,影响心脏功能.

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