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冠状动脉微血管功能障碍与1型糖尿病中心脏能量损害之间的关系
G Nallur Shivu1, T T Phan, K Abozguia
1Department of Cardiovascular Medicine, University of Birmingham, Edgbaston, Birmingham, UK. drgani23@gmail.com
Circulation
|March 3, 2010
概括
1型糖尿病会损害年轻人的心脏能量,无论疾病持续时间如何. 这种心脏功能障碍与微血管问题无关,这表明代谢问题是主要原因.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 代谢研究研究 代谢研究
背景情况:
- 没有症状的糖尿病患者经常表现出心脏能量受损,这可能是心力衰竭的潜在前体.
- 1型糖尿病 (T1DM) 可能会显著影响心脏能量代谢,即使没有症状.
研究的目的:
- 调查微血管功能障碍在T1DM患者心脏能量受损的发展中的作用.
- 评估T1DM无症状个体的心脏能量和微血管功能.
主要方法:
- 招募了25名无症状T1DM受试者 (新诊断和持续时间较长) 和26名健康对照.
- 使用心声回声学,运动心电图,磁共振光谱学和压力磁共振成像.
- 评估了脂蛋白/玛-ATP比率和心肌输液储备指数.
主要成果:
- 与对照组相比,T1DM受试者,无论是新诊断的还是持续时间较长的,都显示了相对照组相比显著降低的脂蛋白/马-ATP比率.
- 在新诊断和较长时间的T1DM组之间,没有观察到脂蛋白/玛-ATP比率的显著差异.
- 长期T1DM患者的心肌输液储备指数较低,但与脂蛋白/玛-ATP比率没有发现相关性.
结论:
- 没有并发症的T1DM的年轻人表现出心肌能量受损,独立于糖尿病持续时间.
- 在T1DM中心脏能量受损与冠状动脉微血管功能障碍无关.
- 代谢功能障碍,而不是微血管功能障碍,被认为是T1DM心脏能量障碍的主要驱动因素.
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