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Updated: Apr 2, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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IL25引发了一种多强的原生细胞群,促进T(H) 2细胞因子反应

Steven A Saenz1, Mark C Siracusa, Jacqueline G Perrigoue

  • 1Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Nature
|March 5, 2010
PubMed
概括

干白素-25 (IL-25) 诱导肠道中的多能原始细胞 (MPP),促进T辅助体2 (T(H) 2) 免疫反应. 这一发现揭示了一个新的先天性免疫路径,对虫感染免疫至关重要.

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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