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Updated: Jun 15, 2026

Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage
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Published on: May 6, 2020

用于测量MutS与DNA错配对结合的DNA剪刀装置

Hongzhou Gu1, Wei Yang, Nadrian C Seeman

  • 1Department of Chemistry, New York University, New York, New York 10003, USA.

Journal of the American Chemical Society
|March 9, 2010
PubMed
概括

研究人员创建了一个DNA纳米机械装置来测量像MutS这样的DNA曲蛋白质所做的工作. 这种创新工具通过监测结构变化和光信号来量化蛋白质结合能量.

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Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Mismatch Repair

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Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...