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Updated: Apr 13, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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在瘤性压力介导的p53反应中,转录独立的ARF调节

Delin Chen1, Jing Shan, Wei-Guo Zhu

  • 1Institute for Cancer Genetics, and Department of Pathology and Cell Biology College of Physicians & Surgeons, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA.

Nature
|March 9, 2010
PubMed
概括

瘤抑制剂ARF在正常细胞中不稳定,但在癌症中稳定. 一种新发现的全方位化酶,ULF,针对ARF进行降解,揭示了一个动态的ARF-p53通路,对瘤抑制至关重要.

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