在活捐赠后的外科手术期间死亡率和长期存活率
Dorry L Segev1, Abimereki D Muzaale, Brian S Caffo
1Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. dorry@jhmi.edu
JAMA
|March 11, 2010
概括
活体脏捐献的手术死亡率很低,为每10,000名捐献者中3.1人. 活捐赠者的长期存活率与匹配的非捐赠者的长期存活率相似,这表明了该程序.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植手术 移植手术
- 公共卫生 公共卫生
背景情况:
- 每年有超过6000名健康的美国人接受切除术,以供活体脏捐献.
- 由于单中心纵向结果研究的概括性有限,安全问题仍然存在.
研究的目的:
- 分析活捐赠者选择和结果的国家趋势.
- 估计不同捐助群体的短期运营风险.
- 为了比较活体捐赠者和匹配的非捐赠者队列之间的长期死亡率.
主要方法:
- 利用了80347名活体脏捐赠者的国家注册 (1994-2009).
- 随访时间中位数为6.3年.
- 从NHANES III参与者中选择了一个匹配的队列,不包括那些有捐赠禁忌的人.
主要成果:
- 手术死亡率为每10,000名捐赠者中3.1,在15年内没有变化.
- 在男性,黑人和高血压患者中观察到更高的外科死亡率.
- 活体捐献者的长期死亡风险并不高于匹配的非捐献者.
结论:
- 活体脏捐献表明,与健康,匹配的队列相比,死亡率没有显著增加.
- 活捐赠者和非捐赠者之间的长期存活率是可比的.
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