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身体性认同是的细胞自主性
1Division of Developmental Biology The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh Roslin Midlothian EH25 9PS tel: 0131 527 4222.
Nature
|March 12, 2010
概括
在鸟类中,体细胞具有内在的性别认同,这意味着性差异化是细胞自主的. 这挑战了哺乳动物性别确定模型在脊椎动物中的普遍应用.
科学领域:
- 发育生物学 发展生物学
- 遗传学 是一个遗传学.
- 比较生理学比较生理学
背景情况:
- 哺乳动物的性别决定模型涉及性无关的胚胎在一个短暂的性别决定基因下分化.
- 该模型对包括鸟类在内的所有脊椎动物的适用性仍未确定.
- 鸟类的性别确定机制需要进一步研究,特别是关于体细胞的身份.
研究的目的:
- 为了研究鸟类的性别决定机制,使用自然存在的侧面生殖.
- 为了测试这个假设,雄性和雌性鸟类体细胞具有固有的性别认同.
- 为了比较鸟类的性别确定与混合性喜梅拉的哺乳动物模型.
主要方法:
- 分析了三只侧面生殖器形,它们的两侧表现出雄性和雌性特征.
- 在相互性别的胚胎之间手术移植假设的中皮层,以创建男性:女性基马性生殖腺.
- 使用细胞标记物检查宿主性腺内的供体细胞行为和身份.
主要成果:
- 基南德罗形被证实是真正的雄性:雌性喜梅拉,表明固有的体细胞性别认同.
- 在的混合性仿真体中,捐赠细胞被排除在功能性淋巴体结构之外,与哺乳动物不同.
- 在雄性宿主发育中的丸中移植的女性细胞保留了女性身份,并表达了女性功能标志物.
结论:
- 鸟类体细胞具有固有的性别认同,独立于宿主的整体性别.
- 鸟类的性差异化在很大程度上是细胞自主,不同于一般化的哺乳动物模型.
- 这项研究为跨脊椎动物类的不同性别决定机制提供了关键证据.
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