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免疫力,炎症,以及癌症
Sergei I Grivennikov1, Florian R Greten, Michael Karin
1Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, 92093, USA.
Cell
|March 23, 2010
概括
炎症和免疫显著影响癌症的发展,影响瘤的生长,扩散和治疗反应. 了解这些复杂的相互作用揭示了癌症预防和治疗的新治疗点.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 炎症是癌症所有阶段的关键因素,从发病到转移.
- 瘤透免疫细胞和癌细胞参与复杂的分子交叉声.
- 免疫监测和治疗反应是由炎症过程调节的.
研究的目的:
- 审查炎症和免疫力影响瘤发展的机制.
- 确定癌症治疗和预防的潜在新目标.
主要方法:
- 关于癌症炎症和免疫机制的文献综述.
- 免疫细胞和癌细胞之间的分子交叉声的分析.
- 讨论治疗和预防策略.
主要成果:
- 炎症驱动瘤的启动,促进,恶性转化,入侵和转移.
- 免疫细胞的透及其与癌细胞的相互作用是瘤进展的关键.
- 已经确定了调解这些相互作用的特定分子途径.
结论:
- 炎症和免疫力是癌症生物学的核心.
- 针对炎症和免疫路径为新型癌症治疗和预防策略提供了有希望的途径.
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