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Updated: May 5, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

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鉴定了两种在进化过程中保存的基因,这些基因调节了被吞的亡细胞的处理过程

Jason M Kinchen1, Kodi S Ravichandran

  • 1Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA. kinchen@virginia.edu

Nature
|March 23, 2010
PubMed
概括

科学家们发现SAND-1 (Mon1) 和CCZ-1 (Ccz1) 对于清除亡细胞至关重要. 这些蛋白质调节细胞成熟,通过确保多细胞生物体的正确尸体清除来预防自身免疫性疾病.

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
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