自我耐受性和自身免疫性
1Department of Microbiology and Immunology, Jonsson Comprehensive Cancer Center, University of California, Los Angeles 90024-1747.
Cell
|May 17, 1991
概括
了解自我耐受性和自身免疫性的进展揭示了免疫细胞耐受性和新型疾病模型的新机制. 这项研究为更有效的自身免疫性疾病治疗铺平了道路.
科学领域:
- 免疫学 免疫学 免疫学
- 自免疫性研究 自免疫性研究
- 宽容机制 宽容机制
背景情况:
- 自我耐受和自身免疫是快速发展的领域.
- 了解这些过程对于开发新疗法至关重要.
研究的目的:
- 探索最近在自我耐受和自身免疫研究方面的进展.
- 突出新疾病模型的发展和对病原机制的理解.
主要方法:
- 在T和B细胞中定义耐受性诱导机制.
- 创建新的转基因动物模型 (转基因大鼠和老鼠).
- 精确识别致病性淋巴细胞的抗原和受体.
主要成果:
- 在T细胞和B细胞中确定了至少两种诱导耐受性的机制.
- 开发了新型易受疾病 (HLA-B27转基因大鼠) 和抗病 (I-E/I-Ak NOD转基因小鼠) 菌株.
- 在特定模型中精确定义了致病性淋巴细胞的抗原和抗原受体.
结论:
- 新的知识大大提高了对自我耐受性和自身免疫性的理解.
- 这些发现预计将导致对自身免疫性疾病开发更有效的疗法.
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