功能性超分支聚合物:使用设计的大分子分子进行向的体内19F磁共振成像
Kristofer J Thurecht1, Idriss Blakey, Hui Peng
1Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, University of Queensland, St. Lucia, QLD, 4072, Australia.
Journal of the American Chemical Society
|March 30, 2010
概括
我们在10分钟内使用-19磁共振成像 (19F MRI) 开发了用于体内成像的新型超分支聚合物. 这些生物相容的聚合物易于功能化,有望作为先进的MRI对比剂用于跟踪和准.
科学领域:
- 聚合物化学 聚合物化学
- 医疗成像医学成像
- 纳米技术 纳米技术
背景情况:
- 目前的MRI对比剂在灵敏度和准方面存在局限性.
- 需要先进的成像剂来进行体内追踪和诊断.
研究的目的:
- 设计和合成用于19FMRI的新型超分支聚合物.
- 评估这些聚合物的生物相容性和功能化潜力.
- 评估它们作为下一代MRI对比剂的实用性.
主要方法:
- 高分支聚合物的合成.
- 链延伸用聚乙烯糖醇甲基乙烯酸盐 (PEGMA) 进行生物相容性.
- 聚合物骨干的功能化.
- 在体内成像使用19FMRI.
主要成果:
- 成功设计和合成超分支分子.
- 在不到10分钟的时间内使用19FMRI实现了体内成像.
- 在链延伸后与PEGMA证明了细胞相容性.
- 易于功能化,具有可访问和正确的连接体呈现.
结论:
- 超分支聚合物对于快速的体内19FMRI是有效的.
- 这些聚合物具有良好的生物相容性和多功能功能.
- 它们代表了一种有前途的新型MRI对比剂,用于跟踪和定位应用.
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