夜间的正面液体转移:在患有心力衰竭的男性中,阻塞性和中央睡眠呼吸暂停的病原发生的统一概念
Dai Yumino1, Stefania Redolfi, Pimon Ruttanaumpawan
1Toronto General Hospital/University Health Network, 9N-943, 200 Elizabeth St, Toronto, Ontario M5G 2C4, Canada.
Circulation
|March 31, 2010
概括
夜间的正面液体转移有助于心力衰竭患者的阻塞性睡眠呼吸暂停 (OSA) 和中央睡眠呼吸暂停. 持续正气道压力 (CPAP) 可以通过防止部液体积累来缓解OSA.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和中央睡眠暂停在心力衰竭 (HF) 患者中很普遍.
- 液体再分配和子周长变化与睡眠呼吸暂停的发病有关.
- 持续正气道压力 (CPAP) 是一种常见的OSA治疗方法.
研究的目的:
- 在HF患者中,研究一夜间面液位移,子周长和睡眠呼吸暂停严重程度之间的关系.
- 为了确定CPAP是否减轻OSA并防止部液体积累.
主要方法:
- 在57名HF患者 (排泄分数≤45%) 进行了多梦摄影.
- 测量包括腿部液体体量,子周长和穿皮Pco在一夜之间发生的变化.
- 患者被分为阻塞性主导和中心主导组;OSA患者接受CPAP.
主要成果:
- 在阻塞性主导的OSA中,腿部液体体积与子周长和呼吸暂停-呼吸暂停指数 (AHI) 相反相关.
- 在中心主导的睡眠呼吸暂停中,腿部液体体积与AHI和子周长相反相关,并且与Pco直接相关.
- CPAP治疗有效地缓解了OSA,并防止过夜增加子周长.
结论:
- 夜间的正面液体转移是心力衰竭中OSA和中央睡眠呼吸暂停病变的重要因素.
- 液体再分配在HF人群中的这些睡眠障碍中起着统一作用.
- CPAP疗法在管理部与OSA相关的液体转移方面表现出有效性.
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