皮层输入的同步最大限度地提高了皮层的可靠性
Hsi-Ping Wang1, Donald Spencer, Jean-Marc Fellous
1Howard Hughes Medical Institute, Computational Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037, USA. ping@salk.edu
Science (New York, N.Y.)
|April 3, 2010
概括
同步的胸膜输入可靠地驱动视觉皮层神经元. 最佳的信息流入皮质取决于平衡的激发和抑制,这表明尖峰同步是皮质功能的关键.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 塔拉姆输入显著影响主要视觉皮层 (V1) 神经元.
- 尽管它们有很大的影响,但乳头突触仅占4层状星状细胞总突触的很小一部分 (~5%).
研究的目的:
- 为了建模向V1层4状星状细胞的前刺激和抑制输入.
- 为了研究同步的thalamic输入和尖峰传输可靠性之间的关系.
- 探索皮层刺激-抑制平衡在关闭信息流中的作用.
主要方法:
- 利用来自猫初级视觉皮层的体内记录.
- 开发了前突触输入的计算模型.
- 分析了峰值传输可靠性作为同步的thalamic输入数和时间的函数.
主要成果:
- 尖端传输可靠性急剧增加,在5毫秒窗口内有20-40个同步的thalamic输入.
- 尖峰传输的峰值能量效率发生在这个最佳的同步范围内.
- 背景皮质刺激和抑制的平衡调节了同步输入的最佳范围.
结论:
- 同步的thalamic输入对于V1.1中可靠的尖峰传输至关重要.
- 皮质刺激-抑制平衡作为信息流的守门人.
- 在小群体中,神经突起同步可能是有效的皮质信息处理的一般原则.
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