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Transcriptome-Wide Profiling of Protein-RNA Interactions by Cross-Linking and Immunoprecipitation Mediated by FLAG-Biotin Tandem Purification
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通过PAR-CLIP进行RNA结合蛋白和microRNA点位的全转录组识别

Markus Hafner1, Markus Landthaler, Lukas Burger

  • 1Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 186, New York, NY 10065, USA.

Cell
|April 8, 2010
PubMed
概括

研究人员在转录组中绘制了RNA结合蛋白 (RBP) 和microRNA-ribonucleoprotein (miRNP) 的结合位. 这种高分辨率的绘图揭示了遗传变异如何影响复杂疾病.

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Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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