调节T2放松时间由光诱导的,可逆聚合磁纳米粒子的调节
Elizabeth A Osborne1, Benjamin R Jarrett, Chuqiao Tu
1Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA.
Journal of the American Chemical Society
|April 9, 2010
概括
研究人员使用氧化铁纳米粒子和光敏感分子开发出可逆T2对比剂. 这种智能代理可以动态改变其聚合状态和MRI信号,使其在实时医学成像和基因报告中的潜在应用成为可能.
科学领域:
- 纳米技术纳米技术
- 生物医学成像技术 生物医学成像技术
- 材料科学 材料科学 材料科学
背景情况:
- 氧化铁纳米粒子被广泛用于MRI对比剂.
- 开发具有可调节性质的"智能"对比剂是一个活跃的研究领域.
- 响应光的分子开关可以精确控制材料的特性.
研究的目的:
- 为了合成和表征一种新的,可逆的T2对比剂.
- 为了研究纳米粒子的光诱导聚合和分散.
- 评估这种药物在动态MRI监测和基因报告方面的潜力.
主要方法:
- 交叉连接的阳离子德克斯涂层氧化铁纳米颗粒的合成.
- 螺旋 (SP) /美洛 (MC) 的共价合. 敏感光的图案.
- 在黑暗和光明条件下,纳米粒子大小和T2放松时间的表征.
主要成果:
- 合成的药物表现出由光引起的可逆聚合和分散.
- 可见光照射导致T2放松时间缩短了33.7%.
- 纳米粒子大小在聚合时从双模分布转移到单个群体.
结论:
- 开发的"智能"T2剂为动态MRI监测提供了可逆性.
- 光响应性表明,它们有可能作为MRI基因记者用于光酶表达系统.
- 这项工作为先进的,可控制的生物医学成像应用开辟了道路.
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