静脉血栓栓塞的危险因素:来自哥本哈根城市心脏研究的结果
Anders G Holst1, Gorm Jensen, Eva Prescott
1Danish Arrhythmia Research Center, Department of Cardiology B2142, University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. anders@kanten.dk
Circulation
|April 21, 2010
概括
肥胖和吸烟是静脉血栓栓塞 (VTE) 的重要危险因素. 与其他心血管标志物不同,高体重指数和吸烟习惯强烈预测VTE的发生.
科学领域:
- 心血管医学 心血管医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明,动脉样硬化疾病风险因素与静脉血栓塞栓症 (VTE) 之间存在联系,但研究结果不一致.
- 研究强调需要澄清VTE的风险因素,特别是与动脉样硬化疾病重叠的风险因素.
研究的目的:
- 确定静脉血栓塞栓症 (VTE) 的关键风险因素.
- 专门调查动脉样硬化疾病风险因素与静脉样硬化发病率之间的关联.
主要方法:
- 使用哥本哈根城市心脏研究 (1976-2007) 的数据进行的前性队列研究.
- 分析包括18954名受试者,随访时间为360,399人年.
- 根据年龄和日历时间调整的多变量模型被用于评估VTE的风险因素.
主要成果:
- 肥胖 (BMI ≥35与<20) 显著增加了静脉瘤风险 (HR=2.10).
- 吸烟 (≥25克/天) 与52%的静脉瘤风险增加有关 (HR=1.52).
- 更高的透析血压和男性性别也与增加的VTE风险相关,而更高的家庭收入显示有保护作用.
结论:
- 肥胖和吸烟被确定为静脉血栓塞栓症 (VTE) 的重要危险因素.
- 在这项研究中,传统的心血管风险因素,如胆固醇水平,甘油三和糖尿病,没有发现与VTE有关.
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