对于1,3-丁与甲醇的选择性端粒化,高效的大型素
Mathieu J-L Tschan1, Eduardo J García-Suárez, Zoraida Freixa
1Institute of Chemical Research of Catalonia (ICIQ), Avinguda Paisos Catalans, 16, 43007 Tarragona, Spain.
合成了新的庞大的氨酸配体,并测试了1,3-丁与甲醇的选择性端粒化. 一个连接体"mono-xantphos"在产量,选择性和稳定性方面表现出优异的性能,用于生产1-methoxyocta-2,7-diene (1-MOD).
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
- 有机合成 有机合成
背景情况:
- 催化端粒化对于生产有价值的化学中间体至关重要.
- 开发高效的连接物是改善催化剂性能和过程经济学的关键.
- 陶氏1 octene工艺依赖于1-methoxyocta-2,7-diene (1-MOD) 作为一个关键的中间体.
研究的目的:
- 为了合成用于催化反应的新型大型素连接体.
- 为了评估这些配体在1,3-丁与甲醇的选择性端粒化中的有效性.
- 为了确定生产1 - 甲二甲-2,7-二烯 (1-MOD) 的优质配体.
主要方法:
- 合成含有双,2-甲基纳或桑部分的大型素配体.
- 使用合成的配体制备单-(0) -dvds复合物.
- 在1,3-丁与甲醇的端粒化过程中对合物复合物的催化试验.
主要成果:
- 几个合成的氨酸配体比三氨酸 (PPh3) 提高了选择性和产量.
- 配体 2,7-di-tert-butyl-9,9-dimethylxanthen-4-yl-diphenylphosphine (4,"单一-xantphos") 显示出了极好的性能. 这是一个非常好的表现.
- "Mono-xantphos"在催化过程中表现出高产量,选择性和稳定性.
结论:
- 大量的素配体,特别是"单-桑",为催化端粒化提供了显著的优势.
- 开发的催化系统提供了一条有效的路径到1-methoxyocta-2,7-diene (1-MOD).
- 这项研究有助于优化生产关键工业中间产品的工艺.
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