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Updated: Jun 13, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
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在肌缩性侧面硬化症中,optineurin的突变

Hirofumi Maruyama1, Hiroyuki Morino, Hidefumi Ito

  • 1Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.

Nature
|April 30, 2010
PubMed
概括

选择性尿素 (OPTN) 基因的突变与肌缩性侧面硬化症 (ALS) 的发病有关. OPTN突变破坏了核因子kappa B (NF-kappaB) 的调节,这表明ALS的新治疗点.

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