预防结直肠癌的一次性灵活西格莫多斯科比查:多中心随机对照试验
Wendy S Atkin1, Rob Edwards, Ines Kralj-Hans
1Department of Surgery and Cancer, Imperial College London, London, UK. w.atkin@imperial.ac.uk
Lancet (London, England)
|May 1, 2010
概括
对于年龄在55至64岁的成年人来说,单次灵活的西格莫多斯科皮查显著降低了结直肠癌的发病率和死亡率. 这种安全和实用的测试提供了对疾病的持久保护.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症相关死亡的主要原因.
- 有效的查策略对于早期检测和预防至关重要.
- 这项研究研究了在特定年龄组中单个灵活的西格莫显微镜查的长期影响.
研究的目的:
- 评估一次性灵活的西格莫多斯科比查在降低CRC发病率和死亡率方面的有效性.
- 评估这种查方法的长期益处和安全性.
- 确定需要查的个体数量,以防止一个CRC病例或死亡.
主要方法:
- 这是一项大规模的随机对照试验,涉及14个英国中心的17万多名参与者.
- 参与者被随机分配到接受灵活的西格莫视镜查或在对照组中.
- 主要结局包括CRC发病率和死亡率,以及治疗意向和每条协议分析.
主要成果:
- 在治疗意向分析中,灵活的西格莫多斯科比查减少了23%的CRC发病率和31%的死亡率.
- 每项协议的分析显示,查患者的发病率降低了33%,死亡率降低了43%.
- 观察到远端CRC发病率显著减少50%. 预防一个CRC诊断或死亡所需的查人数分别为191人和489人.
结论:
- 灵活的半导体镜是一种安全而实用的查工具.
- 在55岁至64岁之间提供一次性查,在减少CRC方面提供了实质和持久的好处.
- 这种干预措施代表了预防CRC的公共卫生价值战略.
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