赛斯塔丁C和对比引起的急性损伤
Carlo Briguori1, Gabriella Visconti, Natalia V Rivera
1Interventional Cardiology, Clinica Mediterranea, Via Orazio, 2, I-80121, Naples, Italy. carlobriguori@clinicamediterranea.it
Circulation
|May 5, 2010
概括
赛斯丁C (CyC) 提供了一种敏感的方法,用于在慢性病患者中早期检测对比诱导的急性损伤. 较高的CyC水平预测重大不良事件,有助于风险评估.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
背景情况:
- 血清肌素 (sCr) 是急性功能变化的常见但不那么敏感的标志物.
- 赛斯他C (CyC) 在检测功能快速变化的过程中表现出更高的灵敏度.
研究的目的:
- 评估Cystatin C (CyC) 作为对比引起的急性损伤 (CI-AKI) 的早期诊断和预后标志物.
- 为了比较CyC的预测值与血清肌素 (sCr) 在患有慢性脏病的患者接受血管造影或血管造形术.
主要方法:
- 一项涉及410名慢性病患者的研究,这些患者正在接受血管造影/血管造形术.
- 测量sCr在基线,24小时和对比后48小时;CyC测量在基线和24小时.
- 在12个月后评估主要不良事件 (死亡,透析).
主要成果:
- CI-AKI (sCr增加≥0.3 mg/dL) 在8.2%的患者中发生.
- 在24小时内,CyC的10%增加确定了21.2%的患者有CI-AKI风险.
- 升高的CyC和/或sCr水平与12个月的重大不良事件发生率显著增加有关.
结论:
- 赛斯塔丁C是一种可靠的标记物,用于在慢性病患者中早期诊断CI-AKI.
- 在对比介质暴露后,CyC作为主要不良事件的有价值的预后指标.
- 这些发现支持使用CyC来提高干预性心血管程序中的风险分层.
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