在无症状个体中运动血压和未来的心血管死亡
Sandra A Weiss1, Roger S Blumenthal, A Richey Sharrett
1Brigham and Women's Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA.
Circulation
|May 5, 2010
概括
在无症状个体中,运动时血压升高与心血管疾病 (CVD) 死亡风险增加有关. 具体来说,布鲁斯第二阶段的血压超过180/90毫米升,可以确定非高血压个体的心血管疾病死亡风险增加.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 预防医学 预防医学
背景情况:
- 过度炼血压 (BP) 是已知的未来高血压的预测因素.
- 运动高血压与心血管疾病 (CVD) 死亡率之间的关联仍然存在争议.
研究的目的:
- 在无症状个体中调查运动BP和心血管疾病死亡率之间的关联.
- 确定运动BP是否为心血管疾病死亡提供独立的预测值,特别是在非高血压个体中.
主要方法:
- 来自脂质研究诊所流行研究的6578名无症状参与者的分析.
- 随访20年,评估休息BP,运动BP (布鲁斯阶段2和最大) 和心血管疾病死亡率.
- 使用多变量Cox比例危险模型和重新分类指标.
主要成果:
- 休息时血压与心血管疾病死亡的关联最强,其次是布鲁斯第二阶段和最大运动时血压.
- 在对休息BP进行调整后,运动BP没有显著意义.
- 然而,在非高血压患者中,布鲁斯第二阶段血压>180/90毫米值显著增加了心血管疾病死亡风险,独立于其他因素.
结论:
- 虽然高运动血压与心血管疾病死亡有关,但当考虑休息血压时,其意义会减小.
- 布鲁斯2期血压超过180/90毫米升是非高血压个体中心血管疾病死亡风险增加的关键指标.
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