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甘油三介导途径和冠状动脉疾病:对101项研究的合作分析
1, Nadeem Sarwar, Manjinder S Sandhu
1Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge CB1 8RN, UK. nadeem.sarwar@phpc.cam.ac.uk
Lancet (London, England)
|May 11, 2010
概括
APOA5基因中的遗传变异强烈影响甘油三水平,增加冠心病风险. 这些发现支持高甘油和心脏病途径之间的因果关系.
科学领域:
- 遗传学 是一个遗传学.
- 心血管医学 心血管医学
- 生物化学 生物化学
背景情况:
- 甘油三介导途径与冠心病 (CHD) 之间的因果关系仍然不确定.
- 研究调节甘油三度的遗传变异可以阐明因果关系.
研究的目的:
- 评估阿波利波蛋白A5 (APOA5) 基因中的-1131T>C促进物多态性与甘油三水平和心脏病风险的关联.
- 在大型前性研究中,将基因决定的风险与观察到的风险进行比较.
主要方法:
- 在APOA5基因中 -1131T>C多态 (rs662799) 的基因定型.
- 对心血管疾病风险的病例控制研究 (20,842例,35,206例对照).
- 与前性队列数据 (302,430名参与者,12,785次心血管疾病事件) 的比较以及1795名个体的NMR光谱分析.
主要成果:
- -1131T>C多态性与较高的甘油三度显著相关 (16.0%的C等位基因增加).
- 每个C等位基因都增加了心血管疾病的几率 (OR1.18),与前性数据一致 (HR1.10每16%的甘油三增加).
- 还观察到与较低的HDL胆固醇,较低的阿波利波蛋白AI,更高的阿波利波蛋白B,更高的VLDL颗粒度和更小的HDL颗粒大小的相关性.
结论:
- 这项研究提供了证据,支持甘油三介导途径和冠心病之间的因果关系.
- APOA5遗传变体是了解甘油三在心脏病发病过程中的作用的宝贵工具.
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