在急性严重高血压中,急性损伤和心血管结果
Lynda A Szczech1, Christopher B Granger, Joseph F Dasta
1Department of Medicine, Division of Nephrology, Duke University Medical Center, Box 3646, Durham, NC 27710, USA. szcze001@mc.duke.edu
Circulation
|May 12, 2010
概括
患有急性严重高血压和慢性病的患者患急性损伤 (AKI) 和更糟糕的结局的风险更高. 在这些患者中,AKI显著增加了发病率和死亡率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 临界护理医学 临界护理医学
背景情况:
- 功能障碍对急性严重高血压的结果的影响尚不清楚.
- 慢性病 (CKD) 是一种常见的疾病,影响功能.
- 急性损伤 (AKI) 代表功能显著下降.
研究的目的:
- 评估基线CKD (eGFR) 和AKI与患者结局之间的关联.
- 为了分析急性严重高血压住院患者的结果.
主要方法:
- 利用来自研究急性高血压治疗 (STAT) 登记册的数据.
- 招募了急性严重高血压患者,接受静脉注射抗高血压剂治疗.
- 根据基线eGFR和住院期间AKI的存在对患者进行分类.
主要成果:
- 在急性严重高血压患者中观察到CKD的高患病率 (79%).
- 慢性结核病患者心力衰竭,心肌梗塞和AKI的风险增加.
- AKI与心力衰竭,心脏骤停和90天死亡率的风险更高有关.
- 在住院期间任何eGFR下降都会独立预测死亡风险的增加.
结论:
- 慢性瘤是急性严重高血压入院中经常出现的并发症.
- AKI是一种常见的并发症,特别是在先前患有CKD的患者中.
- 在这种患者群体中,AKI与发病率和死亡率的增加有关.
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