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相关概念视频

Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria. In...
ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...

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相关实验视频

Updated: Jun 13, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

奥利戈皮雷诺提德:具有类似核酸的结构性质的非生物,聚离子寡合体.

Robert Häner1, Florian Garo, Daniel Wenger

  • 1Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland. robert.haener@ioc.unibe.ch

Journal of the American Chemical Society
|May 13, 2010
PubMed
概括

奥利戈皮雷诺提德 (Oligopyrenotides) 是一种新的无生物核酸模仿物,通过烯堆叠形成稳定的杂交物,反映了DNA和RNA的行为. 这些化合物为设计人工自我复制系统提供了潜力.

科学领域:

  • * 超分子化学 超分子化学
  • * 合成生物学 * 合成生物学
  • * 星际生物学 星际生物学

背景情况:

  • *核酸 (DNA和RNA) 是生命的基础,储存和传输遗传信息.
  • *模仿核酸功能的人工系统对于理解生命起源和开发新技术至关重要.
  • * 设计具有类似核酸特性的非生物分子是合成生物学中的一个关键挑战.

研究的目的:

  • *描述一下新一类非生物性寡合体 - - 奥利戈皮雷诺提德的合成和特性.
  • * 调查甲酸和天然核酸之间的结构类比.
  • * 评估奥利戈皮雷诺提德作为人工自我复制系统的模型系统的潜力.

主要方法:

  • * 合成与基结合的烯构建块,使用一种性1,2-氨酸环素单元.
  • *在水溶液中进行杂交研究,以评估寡合物相互作用.
  • * 用热变性和再变性实验来分析杂交稳定性.
  • * 研究盐度依赖的结构多态性.

主要成果:

  • *Oligopyrenotides被成功合成,显示出与核酸的结构相似之处.
  • * 在水溶液中形成了稳定的杂交物质,由烯堆叠相互作用驱动.

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相关实验视频

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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
08:30

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

Chemical Triphosphorylation of Oligonucleotides
13:19

Chemical Triphosphorylation of Oligonucleotides

Published on: June 2, 2022

  • * 氧化烯酸体表现出与DNA和RNA相似的热变性/再变性行为.
  • *盐度影响了寡 Pyrenotides 的结构多态性.

    • 结论:

    • * 酸酸代表了一种新型的非生物分子类别,其结构和功能与核酸有显著的相似之处.
    • * 它们的杂交和多态行为使它们成为研究核酸原理的优秀模型系统.
    • *这些发现为设计人工自我复制系统和合成生命形式开辟了道路.