Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Multiple Allele Traits01:49

Multiple Allele Traits

32.7K
The Concept of Multiple Allelism
32.7K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

7.1K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
7.1K
Cell Diversity01:13

Cell Diversity

5.4K
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
5.4K
Cellular Differentiation00:57

Cellular Differentiation

5.7K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.7K
Genetic Variation01:25

Genetic Variation

1.7K
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
1.7K
Prokaryotic vs. Eukaryotic Cells01:28

Prokaryotic vs. Eukaryotic Cells

7.5K
Prokaryotic and eukaryotic cells represent two fundamental types of cellular organization, differing significantly in structure, complexity, and function. These distinctions underpin the biological diversity seen across domains of life.Prokaryotic Cell CharacteristicsProkaryotic cells, exemplified by bacteria and archaea, are structurally simple and lack membrane-bound organelles, including a nucleus. Their genetic material consists of a single, circular DNA molecule in the nucleoid region,...
7.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

ResMap: A community resource for systematic mapping of therapy-persistent residual cancer cell dependencies across contexts.

Science advances·2026
Same author

Transitive prediction of small-molecule function through alignment of high-content screening resources.

Nature biotechnology·2025
Same author

A phenopushing platform to identify compounds that alleviate acute hypoxic stress by fast-tracking cellular adaptation.

Nature communications·2025
Same author

Targeting PRMT1 Reduces Cancer Persistence and Tumor Relapse in EGFR- and KRAS-Mutant Lung Cancer.

Cancer research communications·2024
Same author

Targeting therapy-persistent residual disease.

Nature cancer·2024
Same author

Small molecule in situ resin capture provides a compound first approach to natural product discovery.

Nature communications·2024
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
查看所有相关文章

相关实验视频

Updated: May 5, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
07:54

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

20.3K

细胞异质性:差异是否会有所不同?

Steven J Altschuler1, Lani F Wu

  • 1Department of Pharmacology, Green Center for Systems Biology, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. steven.altschuler@utsouthwestern.edu

Cell
|May 19, 2010
PubMed
概括
此摘要是机器生成的。

了解细胞异质性至关重要,因为单个细胞的行为可能与人口平均值不同. 这项研究强调了何时考虑细胞间的变异,并提供了分析方法.

更多相关视频

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques
09:48

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques

Published on: June 30, 2017

9.2K
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

6.0K

相关实验视频

Last Updated: May 5, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
07:54

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

20.3K
Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques
09:48

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques

Published on: June 30, 2017

9.2K
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

6.0K

科学领域:

  • 生物学 生物学 生物学
  • 细胞生物学 细胞生物学
  • 系统生物学 系统生物学

背景情况:

  • 生物系统表现出固有的细胞对细胞的变异性.
  • 在生物学中常见的集体测量可能会掩盖单个细胞的行为.
  • 细胞异质性是生物系统的一个基本方面.

研究的目的:

  • 强调细胞异质性在生物研究中的重要性.
  • 确定忽视细胞间差异是有问题的场景.
  • 提供分析和解释细胞异质性的实用策略.

主要方法:

  • 文献审查和现有方法论的讨论.
  • 了解异质性的概念框架.
  • 案例研究示例说明异质性的影响.

主要成果:

  • 异质性普遍存在,并且可以显著影响生物学结果.
  • 总体数据可能不准确地反映单个细胞的反应.
  • 需要特定的分析方法来捕捉和解释异质性.

结论:

  • 细胞异质性是生物学研究中不能忽视的关键因素.
  • 了解单个细胞的行为需要考虑变异性的方法.
  • 讨论的策略为更准确的生物解释提供了一条道路.