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在TLR/IL-1R信号系统中的MyD88-IRAK4-IRAK2复合体中的螺旋组件

Su-Chang Lin1, Yu-Chih Lo, Hao Wu

  • 1Department of Biochemistry, Weill Cornell Medical College, New York, New York 10021, USA.

Nature
|May 21, 2010
PubMed
概括

MyD88-IRAK4-IRAK2死亡域复合体形成了一个独特的螺旋结构,揭示了如何启动Toll-like受体信号. 这一发现澄清了关键信号通路的组装和调节.

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