序列空间和蛋白质宇宙的持续扩张
Inna S Povolotskaya1, Fyodor A Kondrashov
1Bioinformatics and Genomics Programme, Centre for Genomic Regulation, Calle Dr Aiguader 88, Barcelona Biomedical Research Park Building, 08003 Barcelona, Spain.
Nature
|May 21, 2010
概括
蛋白质进化正在进行中,古代蛋白质仍然存在分歧. 序列分歧的限制来自功能约束和健身景观,这表明蛋白质序列宇宙尚未完全探索.
科学领域:
- 进化生物学是进化的生物学.
- 生物化学 生物化学
- 计算生物学是一种计算生物学.
背景情况:
- 蛋白质的结构和功能完整性限制了氨基酸替代.
- 同源蛋白序列分离的全球极限仍然未知.
研究的目的:
- 使用序列分歧数据探索蛋白质进化的极限.
- 为了研究古代蛋白质的分歧速率.
主要方法:
- 制定了一种计算方法来研究蛋白质序列分离率.
- 测量了最后一个普遍共同祖先中存在的蛋白质的分歧率.
主要成果:
- 古代蛋白质继续分离,表明一个不断扩大的蛋白质序列宇宙.
- 由于功能序列稀疏和崎的健身景观,分歧缓慢.
- 大多数地点都受到限制,但补偿性变化允许最终的进化.
结论:
- 经过35亿年,蛋白质分离进化的极限还没有达到.
- 大多数蛋白质的序列相似性极限可能接近随机序列.
相关概念视频
01:13Protein Organization
Overview
01:24Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.
01:13Protein Organization
Overview
01:24Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.
02:26Conservation of Protein Domains
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
02:26Conservation of Protein Domains Over Different Proteins
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...