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这种突变谱是由来自肺癌患者的配对基因组序列揭示的

William Lee1, Zhaoshi Jiang, Jinfeng Liu

  • 1Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, California 94080, USA.

Nature
|May 28, 2010
PubMed
概括

这项研究对一次性肺瘤进行了测序,揭示了超过5万个体质突变,包括编码区域的新奇变异和结构变化. 它强调了在瘤环境中对基因起作用的独特选择压力.

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