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Updated: Jun 12, 2026

Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

分子拥挤通过排除体积效应稳定了折叠的RNA结构

Duncan Kilburn1, Joon Ho Roh, Liang Guo

  • 1T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Journal of the American Chemical Society
|June 5, 2010
PubMed
概括

通过改变溶液平衡,用聚乙烯甘醇 (PEG) 拥挤分子有利于紧的RNA结构. 这项研究表明,PEG-1000在细菌 ribozyme 中诱导了更紧的状态,影响了折叠热力学.

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